1000 Ways to Die is an American docufiction anthology television series that aired on Spike TV from May 14, 2008, to July 15, 2012, and also aired on Comedy Central during its run. The program recreates unusual supposed deaths, true events, and debunked urban legends, and includes interviews with real medical experts who describe the science behind each death. Up until the end of season one, the final story of each episode showed actual footage of dangerous situations that almost ended in death, along with interviews of those involved in the situations. A portion of these deaths have been nominated for or have received a Darwin Award. Ron Perlman served as the narrator on every episode since the third episode (with Thom Beers narrating the first two episodes); beginning with the episode "Tweets from the Dead", Joe Irwin was featured as the replacement narrator.

Spike burned off the final four episodes, ending the series with the airing of "Death, The Final Frontier." 1000 Ways to Die was cancelled after the producers and stars of the show ran a strike against the network.