Rusty treats Early's burns with clown makeup, and reconsiders his allegiance to the clowny lifestyle.
In this 8th episode of season 5 there's a reference to Insane clown Posse.

About Squidbillies:

Squidbillies is Adult Swim's only backwoods comedy starring Appalachian mud squids. Brought to you by Dave Willis (Aqua Teen Hunger Force) and Jim Fortier, Squidbillies is the story of a dysfunctional redneck family and the equally defective Georgia town from which they hail. Early, Granny, and Rusty are proud, beer guzzling, Southern taxpayers who don't take kindly to government intervention or not getting their welfare checks. Come see their ongoing efforts to protect your second amendment rights at http://AdultSwim.com.

About Adult Swim:

Adult Swim is your late-night home for animation and live-action comedy. Enjoy some of your favorite shows, including Robot Chicken, Venture Bros., Tim and Eric, Aqua Teen, Childrens Hospital, Delocated, Metalocalypse, Squidbillies, and more.